Clinical Chemistry Theory Paper

Q1.      The following indicator is used in Mohr’s titration:

a) Potassium dichromate

b) Diphenyl Carbazone

c) Ferric alum

d) Ammonium thiocyanate

e) Potassium chromate


Q2.      In gastric analysis total acidity consists of free acid and:

a) Carbonic acid

b) Hydrochloric acid

c) Lactic acid

d) Pyruvic acid

e) Palmitic acid


Q3.      Properties of C.S. F glucose include:

a) Determination by Glucometer

b) Is lower than blood glucose

c) Is higher than blood glucose

d) Is same as blood glucose

e) Cannot be determined by copper reduction methods


Q4.      Pathological increase in serum cholesterol is associated with:

a) Certain anaemia

b) Diabetes inspidus

c) Nephrotic syndrome

d) Malnutrition

e) Muscle mass


Q5.      The icterus index is the comparison of serum yellow pigment to:

a) Ferricyanide

b) Carotene

c) Ammonium sulphate

d) Standard potassium permanganate

e) Standard potassium dichromate


Q6.      In a normal glucose tolerance test, blood glucose:

a) Never rises

b) Continues to rise for 2 hours

c) Rises to 8.3 mmol/l the end of the first hour and returns to normal by the second hour.

d) Rises to 8.3 mmol/l the end of the first hour and returns to normal in 24 hours.

d) Rises to 5 mmol/l in one hour and then returns slowly to normal by the second hour.


Q7.      Insulin is:

(a)        An enzyme

b) A hormone

c) A hyperglycaemic agent

d) A product of vitamins

e) Related to gall stones


Q8.      The ratio of Plasma to RBC urea concentration is:

a) 1: 2

b) 4: 5

c) 5:4

d) 1:5

e) 1:3


Q9.      Common principles of chromatography include:

a) Partition

b) Liquid – gas

c) Adsorption

d) Absorption

e) Electron transfer


Q10.    Turbidity in C.S.F can be due to the presence of:

a) Anticoagulants

b) Platelets

c) RBC

d) WBC

e) Glucose


Q11     The main bile pigment(s) are/is:

a) Urobilinogen

b) Porphobilinogen

c) Stercobilinogen

d) Urobilin

e) Bilirubin


Q12.    Bile acids are conjugated in the liver by:

a) Bilirubin

b) Amino sulphate

c) Amino acids

d) Gluconic acid

e) Hydrochloric acid


Q13.    Which of the following is true for serum sodium and potassium?

(a) Both are not determined using a flame photometer.

b) Usually potassium remains normal even in disease.

c) Concentrations of both electrolytes in the body vary according to the health status of an individual.

d) Usually sodium remains normal even in the diseased.

e) It is impossible to get very low potassium levels.


Q14.    Potential safety risk/s in a clinical chemistry laboratory includes:

a) Laboratory coats

b) Working hours

c) Laboratory itself

d) Reagents

e) Workers


Q15.    In alkaline pH, azobilirubin appears:

(a)  Red

b) Blue

c) Purple

d) Yellow

e) Violet


Q16.    In chromatography, the distance travelled by solute over the distance

travelled by solvent front is:

(a)        Dependent on the charge of the solute

b) Rf

c) Equal to one

d) More than one

e) Less than one


Q17.    Chemical changes in an atom are controlled by:

(a)  Protons

b) Electrons

c) Neutrons

d) Particles weighing 1/1840 of a proton

e) Electrons and Neutrons


Q18.    Urine Preservatives include:

(a)  Formaldehyde

b) Sodium chloride

c) Sulphuric acid

d) Hydrochloric acid

e) Nitric acid




Q19.    The green colour in Bial’s test indicates the presence of:

(a)        Maltose

b) Arabinose

c) Sucrose

D) Fructose

e) Mannose


Q20.    The percentage transmittance of a solution of O.D = 0.4 is:

(a)        60

b) 30

c) 16

d) 40

e) 50


Q21.    A sugar that gives a red colour with resorcinol on boiling is:

(a)        An aldehyde

b) Glucose

c) Maltose

d) Galactose

e) A ketone


Q22.    The terms oxidation and reduction are said to be:

a) Complementary

b) Synonymous

c) Complex

d) Useful in organic chemistry only

e) Useful in metabolic reactions only


Q23.    Molar concentration of HCl who’s PH = 1.4 is:

a) 26

b) 14

c) 04

d) 06

e) 16


Q24.    Reducing disaccharides include:

a) Ribose

b) Sucrose

c) Galactose

d) Mannose

e) Maltose


Q25     Glucose may be oxidized to:

a) Mannitol

b) An alcohol

c) Glucoronic acid

d) Gluconic acid

e) Carboxylic acid


Q27     Oxidation of bilirubin yields:

a) Stercobilinogen

b) Biliverdin

c) Yellow–orange pigment

d) Urobilinogen

e) Bile–salts


Q28.    Phenyl pyruvic acid in urine can be detected by:

a) 10% Ferric chloride

b) 10% Trichloroacetic acid

c) 10% Ferric hydroxide

d) 10% Ferricyanide

e) 10% Acetic acid


Q29.    The most definitive method of separating and identifying different sugars in

urine is by:

(a)        Fermentation

b) Chemical examination

c) Chromatography

d) Electrophoresis

e) Dialysis


Q30.    In urine electrophoresis, Bence Jones proteins will appear between which bands?

(a)        Beta and Alpha I

b) Beta and Gamma

c) Alpha I and Alpha II

d) Alpha I and Beta

e) Albumin and Alpha I


Q31.    1% urinary glucose increase urine specific gravity by:


a) 030

b) 010

c) 002

d) 003

E) 004


Q32.    Which of the following is the right order of the basic components of a colourimeter?

a) Light source, filter, cuvette, photodetector

b) Light source, cuvette, filter, photodetector

c) Light source, monochromator, cuvette, photodetector

d) Light source, filter, cuvette, monochromator, photodetector

e) Light source, cuvette, monochromator, photodetector



Q33.    When sodium acetate – acetic acid buffer (Pka = 4.7) has a PH of 5.0, then the concentration of sodium acetate is:

(a)        Equal to that of acetic acid

b) ½ of acetic acid

c) 20 times that of acetic acid

d) Twice that of acetic acid

e) 5 of acetic acid


Q34.    The end product of protein metabolism in man is:

(a)        Nitrogen

b) Creatinine

(c)        Ammonia

(d)       Urea

(e)        Uric acid


Q35.    Amylase can be determined in both blood and urine by various methods based on its ability to convert starch to:

(a)        Glucose

(b)       Maltose

c) Lactose

d) Galactose

e) Lactose


Q36.    Elevated values of serum alkaline phosphatase indicate diseases of:

(a)        Pancreas

b) Kidney

c) Liver

D) Bone

e) Brain