Clinical Chemistry Theory Paper

Q.1 Isotopes of an element have:

a) The same number of neutrons

b) Different number of neutrons

c) The same number of protons

d) Same atomic weight

e) Same atomic mass


Q.2. 0.1 N NaOH is made by dissolving:

a) 40 g in 1 litre

b) 5 g in 125 ml

c) 1 g in 100 ml

d) 2 g in 500 ml

e) 1g in 1 litre


Q.3. A control in Clinical Chemistry is:

  1. a) A solution of known concentration
  2. b) A solution of known reference range
  3. c) A solution without a known concentration
  4. d) A solution used to calibrate a machine
  5. e) Same as a standard solution


Q.4. Glucose Tolerance Test is done:

a) To confirm if one is medically fit

b) To assess liver efficiency

c) To assess pancreatic efficiency

d) To confirm kidney dysfunction

e) To confirm Diabetes Inspidus


Q.5. Bile salts are important in:

a) Digestion of proteins

b) Digestion of carbohydrates

c) Absorption of fat-soluble vitamins

d) Absorption of water-soluble vitamins

e) Absorption of fats


Q.6. The presence of amylase in urine is due to:

a) Nephrotic syndrome

b) Liver problem

c) Impaired digestion

d) Mumps

e) Pancreatitis


Q.7. Seliwanoff’s test is positive with:

a) Maltose

b) Galactose

c) Sucrose

d) Lactose

e) Fructose


Q.8. The presence of Bence Jones proteins in urine is due to:

a) Nephrotic syndrome

b) Low molecular weight

c) Multiple myeloma

d) Liver failure

e) Liver cirrhosis


Q.9. A technique for separating sugars is:

a) Electrophoresis

b) Chromatography

c) Ultracentrifugation

d) Decanting

e) Fermentation


Q.10. Diabetes mellitus is associated with:

a) Impaired glucose metabolism

b) Poor appetite

c) Glucosuria

d) Anuria

e) Low renal threshold


Q.11. Achlorhydria is associated with:

a) Pernicious anaemia

b) Poor absorption of Vitamin B12

c) Indigestion

d) Poor night vision

e) Beri- Beri


Q.12. Hydrochloric acid in gastric juice is important in:

a) Converting pepsin to pepsinogen

b) Providing an acid medium for protein digestion

c) Converting pepsinogen to pepsin

d) Buffering of the gastric contents

e) Overcoming alkalinity provided by mucus


Q.13. Occult blood test detects:

a) Invisible blood

b) The amount of blood host in urine

c) Malignancies of Gastro-Intestinal tract

d) Peroxidase activity

e) Presence of dyes in stool


Q.14. Which of the following compounds are carcinogenic?

a) Phenolphthalein

b) Benzidine

c) Ortho-toluidine

d) Guaiacum

e) Hydrogen peroxide


Q.15. High Cerebral Spinal Fluid sugar may be due to:

a) Diabetes mellitus

b) Diabetes inspidus

c) Bacterial infection

d) High blood sugar

e) High glucose synthesis


Q.16. The pH of Hydrochloric acid whose concentration is 0.0002 M is:

a) 0.

b) 0

c) 699

d) 699

e) 8


Q.17. One of the urea estimation techniques does not employ urease:

a) Berthelot’s method

b) Nesslerization method

c) Urastrat method

d) Enzymatic kinetic method

e) Diacetyl monoxime method


Q.18. Methanol, in bilirubin determination:

a) Coverts direct bilirubin to total bilirubin

b) Coverts indirect bilirubin to direct bilirubin

c) Couples with bilirubin to form a purple colour

d) Stops the reaction between bilirubin and diazo reagent

e) Stabilizes the purple colour


Q.19. Peptide bonds in protein:

a) React with Biuret reagent in protein determination

b) Link up Amino Acids to form peptides

c) Are charged and cause proteins to move in electrophoresis

d) Cause coagulation when proteins are heated

e) Cause separation of proteins in Electrophoresis


Q.20. False low bilirubin levels could be due to:

a) Liver failure

b) Use of ethanol

c) Exposure of samples to light

d) Poor separation of samples

e) Use of clotted samples


Q.21. Pandy’s test detects:

a) Excess globulins

b) Excess albumin

c) Serum proteins

d) α – Amylase

e) Lipoproteins


Q.22. Conversion of Biliverdin to bilirubin is a:

a) Oxidation process

b) Reduction process

c) Hydrolysing process

d) Polymerization process

e) Cleavage process


Q.23. Amino acids at their isoelectric pH are:

a) Negatively charged

b) Positively charged

c) Have both a negative and a positive charge

d) Termed as zwitterions

e) Move towards the cathode


Q.24. Ketoacidosis is often associated with:

a) Diabetes mellitus

b) Diabetes inspidus

c) Diarrhoea and vomiting

d) Haemorrhage

e) Incompatible blood reactions


Q.25. Titrimetric analysis can be used in the estimation:

a) Chlorides

b) Proteins

c) Glucose

d) Creatine

e) Urea